CORTICOSTEROID TAPERING DOSE | P – PACK | PREDNISONE MASS CONCENTRATION 7 – DAY PACK | BOX OF 18

P-PACK, ENLARGED YET CONTRACTED TAPERING DOSE OF PREDNISONE
CONCLUDES TREATMENT TARGETS FOR PRIMARY SAFETY AND EFFICACY
ENDPOINTS.
 Efficacy was tolerable across all studied populations with rapid decline in symptoms after
first dose.
 Effectiveness was achieved, at the end of treatment, across all the therapeutic indications
that were intervened.
 Safety data during and post treatment revealed no toxicity or hospitalization for acute or
chronic undesirable pharmacodynamic properties.
 Acceptance of use measured in compliance or adherence was over nine eight percent.
Abstract
It is common practice in ambulatory medicine and outpatient specialties for doctors and care
practitioners to prescribe a course of glucocorticoids as a crucial armamentarium for symptomatic
disease relief, if there is appropriate use. Yet, there are limited and efficacious options for pre
pack corticosteroid protocols that are effective. Our goal was to test the safety, effectiveness and
efficacy of two tapering prednisone therapies for common disease complaints.
Doses were administered only based on rudimentary data of therapy from specific disease
conditions, and a final balancing for a cardinal pack. To comply with standard of care, patients
received referrals to respective specialists as needed.
Methods: The study cohort consisted of a group receiving 60mg- day- one loading dose of
prednisone with tapering versus the other group receiving 80mg loading dose on day one with a
tapering. Each participant started at a different time when they reported sick and were followed
during the treatments. The end points for the two cohorts on the agents were: dose size response,
complaints of adverse effects and adherence to the course.
Results:
Of a total of 109 patients, 30 received the 60mg initiated tapering dose and 79 received the 80mg loading
dose course. The average age for the participants was forty-eight for which majority was male gender. Of
the 30 patients receiving the 60mg loading dose with tapering, the mean of the response is 0.57, with
variance of 0.05 and SD 0.22 CI [0.4101, 0.7327] over the course of the seven days. On the 80mg loading
dose arm, the mean is 0.82 variance of 0.05, SD 0.23 CI [0.6561, 0.9925] . The response percentiles at 25,
50, 75 were 0.43, 0.5, and 0.7 for the 60mg loading dose taper, and 0.73, 0.95, and 0.96 for the 80mg arm.
The two – tailed P value equals 0.0549. At day five, the 80mg loading dose of prednisone was 43% more
effective than the 60mg tapering across all the conditions treated without any adverse events or
hospitalizations. On day three, participants achieved significant recovery for return to work.

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